Consumer and supplier relationships in Internet Essay

The Internet is one of the great inventions of human kind. Go along with the development of science and technology, Internet changed the face of the world. Especially, in business, Internet plays a vital role because it connects all factors to create the success of business. Internet links customers and suppliers into the stable and mutual benefit’s relationship. Firstly, Internet changes the relationship between customers and suppliers from indirect to direct. It helps to eliminate the â€Å"middle – man† to connect directly the customers and suppliers. In the past, there was only way to buy a product that customers went to the store, where they have contract with the suppliers to provide goods for them. Therefore, customers and suppliers never met together in the real meaning. This process increased a lot of costs. However, when Internet developed, customers and suppliers have opportunities to meet together. To buy the stuff, customers can order directly from suppliers through Internet. By this way, not only does the cost decrease, but also the price is more reasonable. The benefit of Internet created the formation and development of E-commerce and net marketplace. According to page 373 in the textbook, â€Å"online consumer sales grew to an estimated $362 billion in 2012, an increase of more than 15 percent over 2010 (including travel services and digital downloads), with 150 million people purchasing online and an additional 34 million shopping and gathering information but not purchasing† (Laudon, K., & Laudon, J., 2014). Secondly, once Internet developed, the relationship between customers and suppliers is push to improve to the partner relationship. Customer became the partner of supplier. The position of both customers and suppliers are equal. Customers don’t depend on the supplier; in contrast, they are more powerful in choosing their suitable suppliers. Thirdly, it increases the satisfaction and quality of customer service. Nowadays, purchasing and exchanging became easier than ever. To attract customers, suppliers have to take care of their customer’s demand and tend to satisfy it because customers have a lot of choices among a thousand of sellers. Customers can take advantage of price, quality as well as model of product. Thus, to make this relationship become a long term collaboration, besides the diversification of products, suppliers must focus on their service to  keep their customers closer. Reference: Laudon, K., & Laudon, J. (2014). Management Information Systems: Managing the Digital Firm (13 Ed.). Upper Saddle River, NJ: Pearson Education.

When Art Speaks: an Analysis of Two Artist and Two Works of Art

When Art Speaks: An Analysis of Two Artist and Two Works of Art Wanda M. Argersinger Southern New Hanpshire University When Art Speaks The Italian Renaissance produced many artists and even more works of art, but there were three artists considered to be the Trinity of Great Masters, Michelangelo, Leonardo da Vinci and Raffaelo Santi, or simply Raphael. While these artists often worked in different mediums, Michelangelo preferred stone and Raphael preferred oil paint. Michelangelo and Raphael were able to portray emotions in their work.In two of these works, The Pieta and La Madonna di San Sisto, these artists were able to bring to works of art the raw emotions felt by their subjects. Though their works are quite different, what they portrayed was often quite similar. One of Raphael’s works called Raphael’s Angels (San Sisto, 1513-1514), speaks to me in many ways. I was familiar with these two cherubs in the Sistine Madonna as they are often copied and hung in offices a nd homes. But it was only recently that I discovered that these two smiling cherubs belong to a larger work of art.These two well-known cherubs are part of a larger oil painting done on canvas titled La Madonna di San Sisto or Sistine Madonna. It was a commissioned piece and the last of Raphael’s Madonnas. When the cherubs are seen alone they are often called Raphael’s Angels, The Sistine Cherubs, and Raphael’s Two Putti. Most of the works of art during the Renaissance had strong religious connections and were done for the church with the intent that it would reside in the church. When we think of this period in art we most often think of Michelangelo’s Sistine Chapel.While Raphael’s Sistine Madonna is in oil, it was done on a flax covered wall in the Benedictine monastery church and was not permanent. The full painting, The Sistine Madonna, shows Mary holding the baby Jesus, sans halo, with two Saints. The cherubs sit at the very bottom of the pic ture, almost out of place. Their cherubic faces and expressions, in my opinion, belie the magnificence and holiness of the rest of the art work. They look puzzled and somewhat bored, a bit mischievous and not at all reverent.The colors are similar to others used during this period but do not contain all the colors used by Michelangelo in his painting of The Sistine Chapel. They are not bright or harsh, but rather muted. There is sparing use of red and blue, but show more use of brown and gold. The curtains and clothes are dark. The images have little shadowing, showing only under the feet of Mary and one of the saints. The lines of the painting show an opened curtain and clouds on which Mary and the saints stand.The cherubs appear to be leaning on a solid surface that is, in fact, the very bottom of the painting, which is the only straight line of the piece. The clothes appear to be flowing, captured by the use of curved lines and shadowing in the folds. The light source appears to be the clouds which are the brightest of the piece. Personally, it is the cherubs that speak to me, and not the entire work of art. I like the playfulness they show in their eyes. I like the idea that not all religious work is completely serious and that some fun exists in religion.Intellectually, I wonder what the purpose Raphael had in including them in a Church commissioned work. This work is much like other works of the time – religious in nature, done in oil, and displayed in a house of worship. No doubt that Rafael was influenced by other artists and the trend in art of the time, and yet from this one work of art, it appears that the artist himself shows his own unique style simply by including the cherubs and their quizzical looks. During this same time period, the famous Michelangelo painted the Sistine Chapel.Though he may be remembered as a painter, he considered himself a sculptor and completed many statues during his lifetime. One in particular, his Pieta, (Rome, 1498) speaks to me in many ways. The Pieta is a marble statue of Mary holding Christ after he was removed from the cross. He lies straddled across her lap with her looking down on him with a solemn face and closed eyes. When looking at the piece it would be difficult not to see the pain of a woman who has lost someone dear to them.Certainly you can see the grief of Mary for the loss of Jesus, but you can also see the grief of many women who have lost someone they love. I am reminded of all women who grieve for the loss of a child. Done in marble, the statue appears to glisten in places and yet seems darker and in others. The lines capture the image of the human form and the folds of the clothes Mary wears. The hard stone she sits upon is barely seen and does not distract from the movement of the other aspects of the piece. Her face appears shaded under the scarf on her head, while light reflects off the body of Christ.The statue shows marvelous detail of Christ’s body includi ng the holes in his hands where he was nailed to the cross. Upon close observance of the statue one can see that Mary does not touch Jesus skin to skin but has a garment under her right hand, while her left hand is away from the body with her palm up. During his life Michelangelo worked for the church under Pope Julius II and for the Medici family that ruled Rome. The majority of his work was religious in nature, as seen in The Pieta and another famous sculpture he did of David.He designed the tombs for the Medici family and also the Medici Chapel. Michelangelo’s work, along with Raphael’s works, follow the works of the time, most being not only religious in nature, but based on the Christian religion and following stories from the Bible. Both painting and sculpting were popular forms of art and capturing the body through use of religious figures played a major part in the subject matters. Whether done in marble, clay, or oil, the pieces of art capture the emotions of life, the human form in almost absolute detail, and the thoughts of society at the time.With Italy being the center of Catholicism and home to the main church, it is no wonder that the majority of the art works during this period are religious in nature. Add to that the fact that many of the pieces were commissioned by one or more arms of the church religion was certainly the major influence on many of the artists. Topalski, Art In Creation, Rapahel’s Angels, Retrieved from http://www. topalski. com/2012/artworks-in-progress-fine-art-in-creation/raphael%E2%80%99s-angels/ Garden of Praise, Pieta, Retrieved from http://www. gardenofpraise. com/art50. htm

Antimitotic Prodrugs Advantages And Disadvantages

Antimitotic Prodrugs Advantages And Disadvantages Abstract The intricate prodrug therapy has made possible the synthesis and identification of novel drug discovery that have significant structural modifications or intermediate derivatives which may facilitated and enhanced therapeutic parameter during in vitro and in vivo studies. Along with improved target delivery of prodrugs provides the capability to not only overcome certain limitation of antimitotic drugs, but to increases the chances to undergo clinical phase trial studies to get in to action. Development of these new prodrugs as improved alternatives gone through from significant challenges; nevertheless these potential therapies also use to analysed and give suggestion about their further development by clinical studies. Introduction Cancer is diseases in which the body’s cells become abnormal and split without control. Cancer cells may show aggression nearby tissues. They may spread through the bloodstream and lymphatic system to other parts of the body. [1, 2, 3]. Now the days there are mainly three types of treatments are in use surgery, radiation and chemotherapy. Among these, surgery and radiotherapy are to be employed for specific treating are and chemotherapy employed during the systemic treatment of metastases in local as well as regional cancer cells. Chemotherapeutic drugs can be divided in to alkylating agents, antimetabolites plant alkaloids (antimitotics), topoisomerase inhibitors, and other antitumor agents. All of these drugs affect the cell division or DNA synthesis and translation, and function in other ways. The proliferation rate is the play the key role in for the effects of these drugs thus; they are not much selective of tumours. Chemotherapy is treatment with drugs that kill cancer cells and make them less active. It is the treatment of disease by chemicals, especially by killing micro-organisms or cancerous cells. In popular usage, it refers to antineoplastic drugs used to treat cancer or the combination of these drugs into cytotoxic standardized treatment regimen. In its non-oncological use, the term may also refer to antibiotics, long time use of chemotherapy consequences natural cell deaths in the treatments of tumour [4]. Sometime these agents produce remission and re-growth which result in proliferation of cancer cells along with resistance of drugs. Although, intense researches have been conducted in the field of cancer, there are some pioneering ideas need to come in this field to decrease toxicities, physicochemical properties and therapeutic index [5]. The use of prodrug is generally established as a strategy to improve the physicochemical, biopharmaceutical or pharmacokinetic properties of pharmacologically potent agents, and thereby increase the develop ability and usefulness of a potential drug [6,7]. The aim of the prodrug establishment is to improve (i) physicochemical properties like solubility, chemical stability, taste and odour etc. (ii) selectivity; (iii) pharmacokinetic and pha rmacodynamic problems and (iv) therapeutic index. Thus; by these improvements, we can overcome the formulation’s challenges of the drugs [8, 9]. The most of the antimitotic prodrugs developed with conjugating prodrug molecules to low to high molecular weight molecules like sugars, enzymes, vitamins, antibodies, polymers and nanoparticals. These are the carriers which transport prodrug in to tumour and drug release with conjugating the drug to the carrier through a spacer that include particular point which make the specific targeting of the drug. These carriers are very complicated in the structure and demand very hard work to make carries linked prodrugs. Hetrogenecity, biodistribution, expression of multidrug resistance, interstitial pressure and amount of the drug reaching to the target site, are the problems which make the task more difficult. Along with that targeting properties will preserved or not with structural changes are major problems in the formulation of carrie r liked prodrug molecules.

Ecological Services Essay Example | Topics and Well Written Essays - 500 words

Ecological Services - Essay Example Ecological services help to maintain these necessary requirements. Decreasing evaporation, maintaining proper water quality, using natural resources for clean energy is all very important in ecological services. Each services carries out a specific role that contributes to one another in some way. Two services that are most important from â€Å"The Ecological Service of Rivers†, includes providing water for drinking and the providing of irrigation water. Each one of these services contributes to eating and drinking which are important for human survival. Without clean water to drink and water to replenish growing seeds, human life could not remain stable. A river is an important provider of drinking water. Providing drinking water is one of the most important ecological services that rivers can provide. Providing clean drinking water allows for human and animal replenishment that is free of toxins. Toxins that can be found in water include pesticides, diseases, parasites and carcinogens. Another reason why drinking water is so important is because of the cleaning it can provide which leads to a safe environment. Clean water can help prep an area for surgery and allow for proper and safe preparation of food. Clean drinking water also continues to help maintain clean drinking water. When clean water is used and then recycled it is easier for water to keep its cleanliness. Irrigation is important for proper vegetation. A rivers ability to provide the ecological service of irrigation helps maintain life. Irrigation can help seeds grow even when an area may be in a drought. Being able to sustain enough water to irrigate crops will provide much vegetation. Irrigation also makes for proper land up keep. Many use irrigation to water plants that don’t produce food. Irrigation can help trees grow which provide oxygen and flowers that provide pollen. Each element of life is important as each life feeds

Case Assignment Example | Topics and Well Written Essays - 250 words

Case - Assignment Example still lacks strong brands, there is high completion, there is lack of strong distribution link, barrier to entry is still low, and price per kilo of butter has dropped from 405 in 1998 to 205 in 2000 (VÃ ¶gtlin 5). In spite of the current challenges facing development and survival of Russian ice-cream industry, there are evidences of its future prosperity. In order to become more structurally active, this market will likely to increase barriers to entry. This will make raw materials for butter readily available for manufactures at cheaper costs. This will also create and capture more value (VÃ ¶gtlin 7). Additionally, this market will create a strong brand identity and increase marketing of products. The number of companies will also be reduced to minimize competition. This will be achieved through buying of smaller players. I recommend that Ice-Filli should adopt and implement a buyout strategy. This is because this company still has a number of weaknesses in improving its managerial and capital resources, which are required to create and implement the existing strategies. I feel this company will be more secure, in the future, if it is managed by an investment group or another company, which can invest the knowledge and capital required to thrive and

Labeling Research Paper Example | Topics and Well Written Essays - 1500 words

Labeling - Research Paper Example While labeling theory is not as popular as it once was, it has not been completely discredited as a way to understand how social processes lead to deviant behavior. Labeling Theory & Who Labels Whom? Labeling theory argues that just observing the delinquent, or its characteristics, will not provide a whole image of deviance or crime. A complete picture has to include community/society responses to such incidents (Traub and Little 291). Labeling theory is used as a way to understand deviant behavior, including crime, as a consequence of social differentiation processes in which some of society's members are singled out, identified, and defined as deviant, while others are not (Traub and Little 289-295). The causal proposition of labeling theory is that the act of treating a person as a deviant, in itself, can lead to deviant behavior on the part of that person. The punishment of deviant behavior often has an ironic effect: efforts at social control lead to decreased control (Schur 10) . Social definitions of deviance and their accompanying social sanctions somehow pressure labeled individuals into further deviant behaviors. Loosely speaking, a "label," or, a definition of a person as deviant, may be thought of as an independent variable, or, a cause of deviant behavior (Akers 121). The process by which a person is labeled as deviant may be summarized as follows. First, an act is deemed as deviant. Second, the person committing the act is deemed as deviant. And third, a moral condemnation is placed upon this person (Traub and Little 289). According to labeling theory, then, reactions to criminal behavior should be considered at least as important as the behavior itself, if not more. Labeling theory took a lesson from Kai Erikson (p. 11), who argued that the "social audience," not the individual, is the critical variable in studying deviance because it is the audience who decides which acts, or types of acts, deserve the deviant label. In their coverage of labeling theory, Traub and Little (p. 290) wrote "it is the definition of an individual's behavior as deviant, rather than the behavior itself, that can cause a marked change in status which transforms a person's conception of self and initiates the process of locking that person into a 'deviant career'." Thus, it is the community and authority figures such as the police, judges, teachers, parents, and psychiatrists, who label persons as "criminal," "delinquent," "bad kid," "mentally ill," "poor student," and so on. Consequences of Labeling Labeling theory argues that public deviant labeling can have a profound impact on the ability of the labeled person to participate in mainstream society. In one sense, this is an all-too-obvious observation. Societal sanctions have obnoxious effects for the offender of social norms. This assumption is central to the classic school in criminology, namely the deterrence approach to crime and punishment (Gennaro 196). This perspective argues that being caug ht and punished for a crime should decrease one's future rate of offending. Punished individuals should tend to desist from crime to avoid the pain of punishment in the future. However, in direct contrast to this traditional view, labeling theory points out that the ability of the individual to engage in rational decision-making is not the only relevant factor in determining the consequences of punishment. Labeling theory looks beyond individual-level processes and

TOMS Shoe Integrated Marketing Communications Plan Essay

TOMS Shoe Integrated Marketing Communications Plan - Essay Example The marketing objectives of the company is to increase the purchase of TOMS shoe among the youth including college students, those who have recently graduated and in general those below the age of 35 years. In addition, the company in its objectives aims at increasing its market share by 20% in the next 3 years by aggressive marketing using advertisements and other outlined promotional techniques. The communication objectives of the company are geared towards increasing by 30% the target audience that is aware of our products during the first year of implementation. It is also the company communication objective to increase the traffic on our website by 40% in the first year of operation. Further the communication objectives of the company are directed towards increasing the number of customers by 15% in the first year. The ultimate objective of the company communication is to increase our overall presence in social networking sites operating in the country and the globe at large.Pre vious research conducted on marketing to the youth has yielded some less positive results. Marketers consider this group as the hardest one to reach. The marketing initiatives will have to be both convincing and interactive with the prospect of dialogue between the company and the youth in a bid to getting feedback on the quality of the products and also on the nobility of its objectives.   The strength of TOMS shoe is that it has a noble cause attached to its marketing initiatives.  ... The ultimate objective of the company communication is to increase our overall presence in social networking sites operating in the country and the globe at large. 1.2 Challenges Previous research conducted on marketing to the youth has yielded some less positive results. Marketers consider this group as the hardest one to reach. The marketing initiatives will have to be both convincing and interactive with the prospect of dialogue between the company and the youth in a bid to getting feedback on the quality of the products and also on the nobility of its objectives. 2. Situational analysis SWOT Analysis The strength of TOMS shoe is that it has a noble cause attached to its marketing initiatives. The fact that one shoe bought will lead to another being donated to African poor is bound to elicit support from the young people who are the target for the designs of shoes to be marketed. The marketing initiative will ensure that customers will spread the goodwill message to others and in turn will create long time loyalty to the brand. One weakness that the brand has is that it is new. Therefore, it will face stiff competition from the already established brands. The brand will also be under immense scrutiny due to the cause that it will further and customers will want to reassurance that what the company preaches to do is what it actually does. This will require additional capital in reassurance of customers. An opportunity presented by this initiative is that it is the first of its kind and therefore may elicit support for the cause in people who always desired to be charitable but could not have had the opportunity to be. The greatest threat to the